Best American Restaurants in Uptown & Andersonville (60640)
5 hand-picked restaurants, critic-reviewed and ranked
Last Updated: January 2026
Our Top Pick
Tweet
Brunch-first cooking with the kind of volume that builds real regulars.
Notable Picks
#1
Tweet
8.4
A high-energy Uptown brunch institution built around big-plate comfort and a steady, neighborhood-regular rhythm. The wins are the savory staples—hashes and benedicts—where the kitchen’s volume shows up as repeatable execution rather than precious plating.
Must-Try Dishes:
Corned beef hash, Eggs Benedict, Coffee cake starter
What makes it special: Brunch-first cooking with the kind of volume that builds real regulars.
#2
Big Jones
8.3
Coastal-Southern cooking with real technique behind the comfort—gumbo, shrimp-and-grits energy, and heritage touches that keep it from feeling like a theme-park menu. It’s best when you anchor with one rich classic and add one bright, snacky side so the meal stays balanced.
Must-Try Dishes:
Shrimp and grits, Gumbo (dark roux style), Mac and cheese
What makes it special: Southern classics done with depth, not shortcuts, in a lively room.
8.2
A classic all-day diner with a massive menu and the kind of steady output that comes from years of high-volume breakfast service. The move is to keep it old-school—pancakes or an omelet—then lean on the portions to carry you through a long day.
Must-Try Dishes:
Buttermilk pancakes, Wild West omelette, Biscuits and gravy
What makes it special: Old-school diner range with reliable, high-volume breakfast execution.
8.2
Vibes:
Quick Bites Champions
Cheap Eats Budget Brilliance
Comfort Food Classics
Solo Dining Sanctuaries
A fast, classic Chicago stand that delivers the core lineup—dogs, burgers, and Italian beef—without trying to modernize the formula. It’s strongest as a quick-hit stop: one signature dog or beef, add fries, and get out while it’s hot.
Must-Try Dishes:
Chicago-style hot dog, Italian beef (dipped), Cheeseburger
What makes it special: A no-nonsense Chicago hot dog and beef stop that stays consistent at speed.
8.1
A neighborhood New American bistro that shines when you treat it like a composed-plate spot with a cocktail-friendly pace. The menu is strongest in the middle—mussels, seasonal proteins, and a few comfort-leaning mains that keep the room feeling celebratory without going formal.
Must-Try Dishes:
Mussels (house styles), Seasonal fish entrée, Burger (when available)
What makes it special: Bistro cooking with a cocktail-bar pulse and a neighborhood core.