What is the best Mexican restaurant in The Mission District?

Loló is our top pick for Mexican restaurants in The Mission District, scoring 8.5/10. Vivid design and Jaliscan-inspired plates with agave-centric cocktails.

Any insider tips for Loló?

Bar seats move faster and get you first dibs on specials.

What should I order at Loló?

Fried avocado taco; tuna tostada; mezcal negroni

When should I visit Loló?

Early evening for bar specials and open tables

Who should go to Loló?

Design-minded taco and mezcal fans

Any insider tips for Tacolicious (Mission)?

Ask for the salsa sampler to tune heat to your table.

What should I order at Tacolicious (Mission)?

Beef and tinga tacos; queso; house margarita

When should I visit Tacolicious (Mission)?

Weekdays 3–6pm for best HH pricing

Who should go to Tacolicious (Mission)?

Taco fans who want margaritas and buzz

Any insider tips for Mosto?

Slide next door after HH for fuller seating if crowded.

What should I order at Mosto?

Mosto margarita; al pastor; michelada

When should I visit Mosto?

Weekdays 5–7pm happy hour window

Any insider tips for Puerto Alegre?

Portions are big—split combos to sample more dishes.

What should I order at Puerto Alegre?

Enmoladas; fajitas; pozole verde

When should I visit Puerto Alegre?

Early evening on weekends for shorter waits

Who should go to Puerto Alegre?

Families wanting a relaxed table-service dinner

Best Happy Hour Mexican Restaurants in The Mission District (94110)

4 hand-picked restaurants, critic-reviewed and ranked

Last Updated: June 2026

Save

Our Top Pick

Loló

Vivid design and Jaliscan-inspired plates with agave-centric cocktails.

Notable Picks

#1 Loló

8.5

$$ Mission

Vibes: Happy Hour Hotspots Date Night Magic Trendy Table Hotspots Girls Night Out Approved

Jaliscan-Californian plates and a serious agave list in a colorful, design-forward room; weeknight drink specials make pre-dinner cocktails popular. Fried avocado tacos and seafood tostadas anchor the menu.

Must-Try Dishes: Fried avocado taco, Tuna tostada, Carnitas en cazuela

What Makes it Special: Vivid design and Jaliscan-inspired plates with agave-centric cocktails.

View Full Review →

#2 Tacolicious (Mission)

8.4

$$ Mission

Vibes: Happy Hour Hotspots Trendy Table Hotspots Group Dining Gatherings Girls Night Out Approved

Neighborhood standby for agave cocktails and mix-and-match tacos with a weekday happy hour that draws after-work crowds. Portions are fair, salsas are bright, and the room hums without getting chaotic.

Must-Try Dishes: Guajillo-braised beef taco, Chicken tinga taco, Queso dip with chips

What Makes it Special: Reliable weekday happy hour with a deep agave program.

View Full Review →

#3 Mosto

8.1

$$ Mission

Vibes: Happy Hour Hotspots Quick Bites Champions Trendy Table Hotspots

Mezcal-focused Mexican cocktail bar with a concise menu of tacos and bar bites plus a value-driven early evening happy hour. Counter seating and standing room keep it casual and fast.

Must-Try Dishes: Al pastor taco, Quesabirria, Chips with guacamole

What Makes it Special: Weekday HH mezcal and margarita deals with tacos to match.

View Full Review →

#4 Puerto Alegre

8.1

$$ Mission

Vibes: Family Friendly Favorites Group Dining Gatherings Comfort Food Classics Birthday & Celebration Central

Old-school sit-down spot for combo plates, enchiladas, and family-friendly service. Comfortable booths and shareable platters suit multi-generational dinners and celebrations.

Must-Try Dishes: Chicken Enmolada + Chile Relleno Combo, Sizzled Fajitas, Pozole Verde

What Makes it Special: Classic sit-down Mexican with big booths and shareable platters.

View Full Review →