Best Late Night Pizza Restaurants in Midtown East (10022)
4 hand-picked restaurants, critic-reviewed and ranked
Last Updated: January 2026
Our Top Pick
Patsy’s Pizzeria
Coal-oven style pies from a long-running New York pizzeria group in a comfortable sit-down space.
Notable Picks
8.6
Patsy’s Pizzeria on 60th brings the brand’s historic coal-oven style to Lenox Hill, serving thin-crust pies and classic Italian starters in a full-service setting. It isn’t a 3am slice joint, but for later dinners and lingering pizza-focused nights, it’s one of the most established options in 10022.
Must-Try Dishes:
Old Fashioned Margherita Pizza, White Pie, Baked Clams
What makes it special: Coal-oven style pies from a long-running New York pizzeria group in a comfortable sit-down space.
8.3
Vibes:
Late Night Legends
Cheap Eats Budget Brilliance
Group Dining Gatherings
Quick Bites Champions
Little Italy Pizza on 3rd Ave is a high-volume Midtown East slice shop turning out classic New York pies and heroes until around 3–4am. With thousands of delivery ratings and steady foot traffic, it’s a reliable stop for big slices, grandma pies, and late-night garlic knots.
Must-Try Dishes:
Cheese Pizza, Grandma Pizza, Garlic Knots
What makes it special: A classic New York slice counter with huge hours and a deep menu that locals actually use.
Worthy Picks
7.9
Vibes:
Cheap Eats Budget Brilliance
Late Night Legends
Quick Bites Champions
Solo Dining Sanctuaries
LaVista is a high-volume neighborhood slice shop known for generous portions, late hours, and a surprisingly broad menu that includes vegan and gluten-free options. It’s more functional than pretty, but locals lean on it for quick, affordable slices and big heroes.
Must-Try Dishes:
Vodka slice, Bruschetta hero, Vegan margherita slice
What makes it special: Dependable, budget-friendly slices with strong delivery and late-night hours.
7.9
La Pizza Italia turns out crisp Roman-style squares and creative slices—like hot honey vodka and burrata-topped pies—until 4am most nights. It’s a compact Midtown East counter spot where late-night crowds grab high-quality slices, pastas, and salads without the tourist markup.
Must-Try Dishes:
Burrata basil slice, Vodka pasta BOGO special, Pepperoni slice
What makes it special: Late hours and frequent deals on slices and pasta near 2nd Avenue.