Best Pizza Restaurants in Midtown East
2 hand-picked restaurants, critic-reviewed and ranked
Last Updated: February 2026
Our Top Pick
My Pie Pizzeria Romana
High-volume Roman-style pizza with crackly, airy slabs and serious topping work.
Notable Picks
8.6
Roman-style al taglio slabs, long-fermented dough, and imported toppings make My Pie the most distinctive slice in this part of Midtown East. Lines move quickly at the narrow counter, and regulars come for crisp, airy squares that eat more like artisanal focaccia than standard New York slices.
Must-Try Dishes:
Truffle Oil and Mushroom slice, Grandma Nonnina square, Buffalo mozzarella Margherita
What makes it special: High-volume Roman-style pizza with crackly, airy slabs and serious topping work.
8.3
Vibes:
Late Night Legends
Cheap Eats Budget Brilliance
Group Dining Gatherings
Quick Bites Champions
Little Italy Pizza on 3rd Ave is a high-volume Midtown East slice shop turning out classic New York pies and heroes until around 3–4am. With thousands of delivery ratings and steady foot traffic, it’s a reliable stop for big slices, grandma pies, and late-night garlic knots.
Must-Try Dishes:
Cheese Pizza, Grandma Pizza, Garlic Knots
What makes it special: A classic New York slice counter with huge hours and a deep menu that locals actually use.